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apalutamide will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicine that happen to be CYP3A4 substrates can result in reduce exposure to those drugs.calaspargase pegol, ethinylestradiol. not kno